Tributyltin azide → Ethyl 5-(1H-tetrazol-5-ylmethyl)imidazo[1,2-a]pyridine-2-carboxylate

HRID 862002노트

반응식

HRID 862002 반응식
[C:1]([CH2:3][C:4]1[N:9]2[CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:12]=[C:8]2[CH:7]=[CH:6][CH:5]=1)#[N:2].[N:18]([Sn](CCCC)(CCCC)CCCC)=[N+:19]=[N-:20]>P(CC1C2N(C=C(C(O)=O)N=2)C=CC=1)(O)(O)=O>[NH:18]1[C:1]([CH2:3][C:4]2[N:9]3[CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:12]=[C:8]3[CH:7]=[CH:6][CH:5]=2)=[N:2][N:20]=[N:19]1

참가 물질

4

반응물 2

HCID 4984872Tributyltin azideHCID 19701198Ethyl 5-(cyanomethyl)imidazo[1,2-a]pyridine-2-carboxylate

생성물 1

HCID 178469441Ethyl 5-(1H-tetrazol-5-ylmethyl)imidazo[1,2-a]pyridine-2-carboxylate

시약·촉매·용매 1

HCID 19701381HCID 19701381, 화합물용매2회

실험 절차

The title material is prepared by heating the title product of Example 99 with azido tributylstannane at 80° C. for 72 h. After cooling to room temperature, the reaction is treated with methanolic HCl for 30 min., diluted with 4N HCl, washed with diethyl ether and concentrated to yield title material.

후처리

  1. washwashed with diethyl ether
  2. concentrationconcentrated
  3. customto yield title material

출처 및 근거

ORD 기록
ord-1add0950defb45b38b2876b3671ad414
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716964

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