Trifluoroacetate → Pixantrone dimaleate

HRID 862164노트

반응식

HRID 862164 반응식
FC(F)(F)C([O-])=O.[NH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:17]2[C:18](=[O:27])[C:19]3[CH:20]=[CH:21][N:22]=[CH:23][C:24]=3[C:25](=[O:26])[C:16]=2[C:15]([NH:28][CH2:29][CH2:30][NH2:31])=[CH:14][CH:13]=1.[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36]>>[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36].[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36].[NH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:17]2[C:18](=[O:27])[C:19]3[CH:20]=[CH:21][N:22]=[CH:23][C:24]=3[C:25](=[O:26])[C:16]=2[C:15]([NH:28][CH2:29][CH2:30][NH2:31])=[CH:14][CH:13]=1

참가 물질

4

반응물 3

HCID 84468Trifluoroacetate2회HCID 134019PixantroneHCID 444266Maleic Acid2회

생성물 1

HCID 9937618Pixantrone dimaleate

실험 절차

exchanging the trifluoroacetate salt of 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione with maleic acid by treating the trifluoroacetate salt with an aqueous solution of maleic acid to form the crystallized 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt.

출처 및 근거

ORD 기록
ord-09310a19981643cdbc36ee915c4fc748
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05717099

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