3-Cyanoandrosta-3,5-diene-17beta-carboxylic acid → N-[1-(3,5-Dimethoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide

HRID 862316노트

반응식

HRID 862316 반응식
[C:1]([C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:22](O)=[O:23])[CH:4]=1)#[N:2].[CH3:25][O:26][C:27]1[CH:28]=[C:29]([C:35]([NH2:38])([CH3:37])[CH3:36])[CH:30]=[C:31]([O:33][CH3:34])[CH:32]=1>>[CH3:34][O:33][C:31]1[CH:30]=[C:29]([C:35]([NH:38][C:22]([C@H:12]2[CH2:11][CH2:10][C@H:9]3[C@H:8]4[C@H:17]([CH2:16][CH2:15][C@:13]23[CH3:14])[C@:18]2([CH3:21])[C:5]([CH:4]=[C:3]([C:1]#[N:2])[CH2:20][CH2:19]2)=[CH:6][CH2:7]4)=[O:23])([CH3:36])[CH3:37])[CH:28]=[C:27]([O:26][CH3:25])[CH:32]=1

참가 물질

3

반응물 2

HCID 153802543-Cyanoandrosta-3,5-diene-17beta-carboxylic acidHCID 157541382-(3,5-Dimethoxyphenyl)propan-2-amine

생성물 1

HCID 57001892N-[1-(3,5-Dimethoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide수율 98%

실험 절차

Following a procedure similar to that described in Preparation 16a, but using 3-cyanoandrosta-3,5-diene-17β-carboxylic acid [prepared as described in Example 1(b)] and 1-(3,5-dimethoxyphenyl)-1-methylethylamine as starting materials, in relative proportions similar to those used in that Preparation, the title compound was obtained in a yield of 98%.

후처리

  1. customin relative proportions similar to those used in that Preparation

출처 및 근거

ORD 기록
ord-a744a9b9026d438fa76e580f7dc1606b
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05717088

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