Bromoacetyl chloride → N-[2-(2,6-Dimethoxy-4-methylbenzoyl)phenyl]-N-methylbromoacetamide

HRID 862403노트

반응식

HRID 862403 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([O:10][CH3:11])[C:4]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][CH3:21])=[O:13].[Br:22][CH2:23][C:24](Cl)=[O:25]>ClCCl.O>[CH3:11][O:10][C:5]1[CH:6]=[C:7]([CH3:9])[CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]([CH3:21])[C:24](=[O:25])[CH2:23][Br:22])=[O:13]

참가 물질

5

반응물 2

HCID 89602Bromoacetyl chlorideHCID 57322216(2,6-Dimethoxy-4-methylphenyl)(2-methylaminophenyl) Ketone

생성물 1

HCID 19062972N-[2-(2,6-Dimethoxy-4-methylbenzoyl)phenyl]-N-methylbromoacetamide수율 99%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매2회

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온도
-10 °C

실험 절차

To a mixture of 10 g of (2,6-dimethoxy-4-methylphenyl)(2-methylaminophenyl) ketone in 100 ml of dichloromethane and 20 ml of water, cooled to -10° C., are added dropwise 6.34 g of bromoacetyl chloride in 20 ml of dichloromethane. The reaction mixture is allowed to return to room temperature and is then stirred vigorously for 2 hours. The phases are separated after settling has taken place and the organic phase is successively washed with water, dried over sodium sulphate and evaporated to dryness to give beige crystals melting at 121° C.; Yield=99%.

후처리

  1. customto return to room temperature
  2. customThe phases are separated after settling
  3. washthe organic phase is successively washed with water
  4. dry with materialdried over sodium sulphate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-2dec987511b04d8389f19d5a5dd0c450
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719143

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