Pyrazole-4-carboxylic acid → Methyl 1H-pyrazole-4-carboxylate

HRID 862479노트

반응식

HRID 862479 반응식
[NH:1]1[CH:5]=[C:4]([C:6]([OH:8])=[O:7])[CH:3]=[N:2]1.[CH3:9][O-].[Na+]>CO.S(=O)(=O)(O)O>[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH3:9])=[O:7])[CH:3]=[N:2]1

참가 물질

5

반응물 2

HCID 3015937Pyrazole-4-carboxylic acidHCID 10942334Sodium Methoxide

생성물 1

HCID 9793760Methyl 1H-pyrazole-4-carboxylate

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 1118Sulfuric Acid용매

실험 절차

4-Pyrazolecarboxylic acid (514 mg) was dissolved in methanol (10 ml) and sulfuric acid (0.25 ml), and the mixture was stirred at room temperature for 2 hours, followed by refluxing under heating for 4 hours. After cooling, a 28% solution (0.95 ml) of sodium methylate in methanol was added to the reaction mixture for neutralization and the solvent was distilled away. Chloroform was added to the residue, and the residue was washed with water and brine and dried over anhydrous magnesium sulfate. The solvent was distilled away to give 433 mg of the title compound.

후처리

  1. temperatureby refluxing
  2. temperatureunder heating for 4 hours
  3. temperatureAfter cooling
  4. distillationthe solvent was distilled away
  5. additionChloroform was added to the residue
  6. washthe residue was washed with water and brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. distillationThe solvent was distilled away

출처 및 근거

ORD 기록
ord-03a04da955174a06bbf4cc1d968eb199
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719155

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