Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (1,2,3,4-Tetrahydroquinolin-2-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 1,2,3,4-tetrahydroquinoline-2-carboxylate | HCID 2736972 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (1,2,3,4-Tetrahydroquinolin-2-yl)methanol | HCID 15052240 | 106.9% |
반응 단계
To a suspension of LiAlH4 (8.3 g, 0.22 mol) in THF (200 mL) was added dropwise 2-methoxycarbonyltetrahydroquinoline (42 g, 0.22 mol) in THF (200 mL) at 0° C. The mixture was stirred for 3 h at room temperature and refluxed for 0.5 h. The excess reagent was decomposed by addition of aqueous sodium hydroxide in THF. To the mixture was added 1N aqueous NaOH, water, and diethyl ether, successively. The organic layer was separated, washed with brine, dried over magnesium sulfate, and concentrated to give 38.4 g of 2-hydroxymethyltetrahydroquinoline (quant).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05719152 |
| 출처 데이터셋 | uspto-grants-1998_02 |
| ORD ID | ord-edf4c1abe13443eb986d015ad3f7fc81 |
| 출처 메모 | uspto-grants-1998_02 |