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Ethyl 5-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)pent-4-enoate → 2-(4-Ethoxycarbonylbutyl)-4-tert-butoxycarbonylaminomethylaniline

HRID 862600
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HRID 862600 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([N+:25]([O-])=O)=[C:14]([CH:16]=[CH:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>C(OCC)(=O)C.[Pt]=O>[CH2:23]([O:22][C:20]([CH2:19][CH2:18][CH2:17][CH2:16][C:14]1[CH:15]=[C:10]([CH2:9][NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[CH:11]=[CH:12][C:13]=1[NH2:25])=[O:21])[CH3:24]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 53964031Ethyl 5-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)pent-4-enoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 196983622-(4-Ethoxycarbonylbutyl)-4-tert-butoxycarbonylaminomethylaniline수율 108%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of ethyl 5-(5-tert-butoxycarbonylaminomethyl-2-nitrophenyl)pent-4-enoate (560 mg, 1.48 mmol) in ethyl acetate (20 mL) was hydrogenated over platinum oxide (100 mg) under atmospheric pressure of hydrogen at room temperature for 2.5 h. The mixture was passed through celite and the filtrate was concentrated to give 560 mg of the title compound (100%).

후처리

  1. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-22ab9fbb19a6431c959843ea78f7af95
출처 데이터셋
uspto-grants-1998_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05719152

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