HCID 22097613, 화합물 → Imidazole-1-butyric acid

HRID 862661노트

반응식

HRID 862661 반응식
[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([O:11]CC2C=CC=CC=2)=[O:10])[CH:5]=[CH:4][N:3]=[CH:2]1>[C].[Pd].C(O)C>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

4

반응물 1

HCID 22097613HCID 22097613, 화합물

생성물 1

HCID 3055390Imidazole-1-butyric acid수율 75%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A mixture of benzyl 4-(1-imidazolyl)butyrate (7.4 g), palladium-carbon (5%)(1.0 g) and ethanol (400 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, and the crystals were recrystallized from ethanol to give 4-(1-imidazolyl)butyric acid (3.4 g, 75%). Colorless prisms. mp. 125°-126° C.

후처리

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customthe crystals were recrystallized from ethanol

출처 및 근거

ORD 기록
ord-0fb17e1b862243f5973735eedc67bc91
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719157

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