Methanesulfonic Acid → 1-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium sulfate

HRID 862709노트

반응식

HRID 862709 반응식
C[S:2]([OH:5])(=[O:4])=[O:3].[OH-].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20]>O1CCCC1>[S:2]([O-:5])([O-:15])(=[O:4])=[O:3].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20]

참가 물질

4

반응물 2

HCID 6395Methanesulfonic AcidHCID 196988161-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium hydroxide

생성물 1

HCID 676602951-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium sulfate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1.09 mlg [sic] (16.78 mol; 1.61 g) of methane-sulfonic acid is added to a solution of 1-methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium hydroxide (3.48 g; 15.35 mol) dissolved in 100 ml of anhydrous tetrahydrofuran. The mixture is stirred under argon at room temperature for one hour. The precipitate which forms is filtered and then rinsed with ether.

후처리

  1. filtrationThe precipitate which forms is filtered
  2. washrinsed with ether

출처 및 근거

ORD 기록
ord-81d2d451e6dc4b3a8b7b808965465d1a
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719187

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