Thionyl Chloride → 3-(4-Fluorophenyl)propionyl chloride

HRID 862753

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:15])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([Cl:15])=[O:12])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 1363023-(4-Fluorophenyl)propionic acid

생성물 1

HCID 219642583-(4-Fluorophenyl)propionyl chloride수율 96.3%

실험 절차

A mixture of 3-(4-fluorophenyl)propionic acid (275.1 g, 1.6 mol) and thionyl chloride (300 mL, 4.1 mol) was heated to reflux for 3 h, cooled to room temperature and distilled under aspirator vacuum to give 287.6 g (96%) of 3-(4-fluorophenyl)propionyl chloride as a pale pink oil, b.p., 120°-122° C./15 mm Hg; IR (neat) 1793,1511 cm-1 ; NMR (DMSO-d6): d7.04-7.32 (m, 4H, Ar), 2.50-2.89 (m, 4H, 2XCH2).

후처리

temperaturewas heated
temperatureto reflux for 3 h
distillationdistilled under aspirator vacuum

출처 및 근거

ORD 기록: ord-a6d7cd04657b4c14adaff9531f96122d
출처 데이터셋: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05719186

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