Thionyl Chloride → 4-(4-Fluorophenyl)butyryl chloride

HRID 862775노트

반응식

HRID 862775 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([Cl:16])=[O:13])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 685244-(p-Fluorophenyl)butyric acid

생성물 1

HCID 232935944-(4-Fluorophenyl)butyryl chloride수율 101.4%

실험 절차

A mixture of 4-(4-fluorophenyl)butyric acid (68.2 g, 0.37 mol) and thionyl chloride (155 g, 1.3 mol) was refluxed for 1.25 h. The mixture was concentrated in vacuo to give 75.3 g (100%) of 4-(4-fluorophenyl)butyryl chloride)

후처리

  1. temperaturewas refluxed for 1.25 h
  2. concentrationThe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-7ba1d7f5539b400a9213a6a23af62fd4
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719186

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