Acetyl chloride → L-Norvaline, methyl ester

HRID 863187

반응식

HRID 863187 반응식
[C:1](Cl)(=O)C.[NH2:5][C@H:6]([C:10]([OH:12])=[O:11])[CH2:7][CH2:8][CH3:9]>CO>[CH3:1][O:11][C:10](=[O:12])[C@H:6]([CH2:7][CH2:8][CH3:9])[NH2:5]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 65098L-Norvaline

생성물 1

HCID 7019097L-Norvaline, methyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 20 mL of methanol was slowly added 2.6 mL acetyl chloride. Then 2.0 g (17.1 mmole) of L-norvaline was added. The solution was heated to reflux and monitored by thin-layer chromatography (TLC) until complete. The methanol was stripped off by rotary evaporation and the resulting oil was pumped under high vacuum overnight to give the title compound. NMR(300 MHZ, CD3OD): δ 4.03 (t, Nva-α, 1H), 3.81 (s, COOCH3, 3H), 1.87 (m, CH2CH2CH3, 2H), 1.44 (m, CH2CH2CH3, 2H), 0.98 (t, CH2CH2CH3, 3H).

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux
  3. customThe methanol was stripped off by rotary evaporation
  4. customwas pumped under high vacuum overnight

출처 및 근거

ORD 기록
ord-d038bcdebc68470bb7cdd8f58e0a9df3
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719296

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