Pyridine → 3-Methylcarbonyloxyquinoline

HRID 863260

반응식

HRID 863260 반응식
[C:1](Cl)(=[O:3])[CH3:2].[OH:5][C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2.N1C=CC=CC=1.C(Cl)Cl>O>[CH3:2][C:1]([O:5][C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:3]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 113763-Hydroxyquinoline

생성물 1

HCID 154938353-Methylcarbonyloxyquinoline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.35 ml of acetyl chloride are added dropwise to a mixture of 2.5g of 3-hydroxyquinoline (prepared by the method described by Mills and Watson in J.Chem. Soc., 97, 753 (1910)), 8.6 ml of pyridine and 50 ml of methylene chloride, while cooling with ice. After the reaction mixture has been stirred at room temperature for 10 minutes, 50 ml of water are added. Customary working up and purification of the crude product by FC over 50 g of silica gel (mobile phase C) gives 3-methylcarbonyloxyquinoline: Rf (A)=0.55; IR (CH2Cl2): 1770(s) cm-1.

후처리

  1. customprepared by the method
  2. custompurification of the crude product by FC over 50 g of silica gel (mobile phase C)

출처 및 근거

ORD 기록
ord-6a16a314908e48289e1152442eec1cdc
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719141

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