Bromine → N-(5-acetylamino-6-bromo-indan-2-yl)acetamide
반응식
[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH2:10][CH:9]([NH:14][C:15](=[O:17])[CH3:16])[CH2:8]2)(=[O:3])[CH3:2].[Br:18]Br>C(O)(=O)C>[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[Br:18])[CH2:10][CH:9]([NH:14][C:15](=[O:17])[CH3:16])[CH2:8]2)(=[O:3])[CH3:2]참가 물질
4
실험 절차
A solution of N-(5-acetylamino-indan-2-yl)-acetamide (9.8 g, 42 mmol) and bromine (8.5 g, 53 mmol) in acetic acid (200 mL) was stirred at room temperature for 3 h. After evaporation of the solvent, the syrupy residue was dissolved in ether and washed with water. The organic layer was washed with aqueous sodium bisulfite and dried over magnesium sulfate. The solvent was concentrated and the resulting solid collected by filtration (10 g, 77% yield).
후처리
- customAfter evaporation of the solvent
- dissolutionthe syrupy residue was dissolved in ether
- washwashed with water
- washThe organic layer was washed with aqueous sodium bisulfite
- dry with materialdried over magnesium sulfate
- concentrationThe solvent was concentrated
- filtrationthe resulting solid collected by filtration (10 g, 77% yield)
출처 및 근거
- ORD 기록
- ord-021d9269f5a9443ba7e198ae3b6dd52c
- 출처 데이터셋
- uspto-grants-1998_02
- 특허 번호
- US05721234
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