Methanesulfonic Acid → HCID 86752152, 화합물

HRID 863587노트

반응식

HRID 863587 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1[CH2:13][NH:14][C@H:15]1[CH:20]2[CH2:21][CH2:22][N:17]([CH2:18][CH2:19]2)[C@H:16]1[CH:23]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[CH3:36][S:37]([OH:40])(=[O:39])=[O:38]>CC(C)=O>[S:37]([OH:40])(=[O:39])(=[O:38])[CH3:36].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1[CH2:13][NH:14][C@H:15]1[CH:20]2[CH2:19][CH2:18][N:17]([CH2:22][CH2:21]2)[C@H:16]1[CH:23]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

참가 물질

4

반응물 2

HCID 6395Methanesulfonic AcidHCID 53856125HCID 53856125, 화합물

생성물 1

HCID 86752152HCID 86752152, 화합물수율 90.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of (2S,3S)-N-(2-methoxy-5-methylsulfonylphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine (400 mg, 0.82 mmol) in acetone (10 mL) was added methanesulfonic acid (0.41 mmol, 39.2 mg). The precipitated white solid was filtered off to give the title compound (218 mg, 30.3%, 1st crop).

후처리

  1. filtrationThe precipitated white solid was filtered off

출처 및 근거

ORD 기록
ord-dc1de828b900414b9045f77505d1865d
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05721255

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