Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dibromoethane → (2-Bromo-ethyl)-(3-fluorobenzyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dibromoethane | HCID 7839 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 3-Fluorobenzylamine | HCID 66853 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (2-Bromo-ethyl)-(3-fluorobenzyl)-amine | HCID 21983578 | — |
반응 단계
Combine 3-fluorobenzylamine (5.0 g, 0.0400 mol), fused sodium acetate (3.28 g, 0.0400 mol) and 1,2-dibromoethane (7.51 g, 0.0400 mol) and reflux for several hours. Pour the mixture into water and add sodium carbonate to create a basic pH. Remove the unreacted 1,2-dibromoethane by distillation. Extract the left-over residue with ether and evaporate to obtain the final, desired compound. The compound can form the hydrochloride salt.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091199B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-581af56aec3a433e9adb69447c08ffc7 |
| 출처 메모 | uspto-grants-2006_08 |