1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane → Bis-Aminoethylglycol

HRID 863735

반응식

HRID 863735 반응식
[N:1]([CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][N:12]=[N+]=[N-])=[N+]=[N-].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[NH2:1][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][NH2:12]

참가 물질

4

반응물 2

HCID 108457051-Azido-2-[2-(2-azidoethoxy)ethoxy]ethaneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 70248Bis-Aminoethylglycol수율 97%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

The diazide (17) (3.55 g, 17.85 mmol) in THF (10mL) was added dropwise into a cold (-5° C.) stirred mixture of lithium aluminum hydride (1.83 g, 48.2 mmol) in THF (20 mL). The reaction mixture was kept at -5° C. and carefully quenched with water (10 mL). The THF layer was filtered to remove the inorganic salts, dried over Na2SO4, and evaporated in vacuo to afford the diamine (18) (2.56 g, 97% yield).

후처리

  1. customwas kept at -5° C.
  2. customcarefully quenched with water (10 mL)
  3. filtrationThe THF layer was filtered
  4. customto remove the inorganic salts
  5. dry with materialdried over Na2SO4
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-7b18f818422b45a7b79aa84b48553855
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05561042

연결된 노트

불러오는 중…