Sodium Iodide → 6-Phenyl-1-hexyl iodide

HRID 863840노트

반응식

HRID 863840 반응식
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=O)=O.[I-:18].[Na+]>CC(C)=O>[C:12]1([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][I:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 130797026-Phenylhex-1-yl methylsulfonate

생성물 1

HCID 145296726-Phenyl-1-hexyl iodide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To 6-phenylhex-1-yl methylsulfonate (4.55 g; 17.3 mmol) dissolved in acetone (100 ml) is added sodium iodide (2.5 g; 173 mmol) and the reaction mixture is heated 2 hours at reflux. The reaction mixture is then concentrated to dryness and partitioned between ether and water. The organic phase is separated, dried, concentrated to dryness and purified with silica chromatography using 10 EtOAc/90 petroleum ether to give 6-phenyl-1-hexyl iodide as a colorless oil which is used directly in Step F.

후처리

  1. temperaturethe reaction mixture is heated 2 hours
  2. temperatureat reflux
  3. concentrationThe reaction mixture is then concentrated to dryness
  4. custompartitioned between ether and water
  5. customThe organic phase is separated
  6. customdried
  7. concentrationconcentrated to dryness
  8. custompurified with silica chromatography

출처 및 근거

ORD 기록
ord-8f17090b939c4349a5cc3b771a243771
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05561143

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