Triethylamine → Acetaldehyde, 2-(2-phenylethoxy)-
반응식
[C:1]1([CH2:7][CH2:8][O:9][CH2:10][CH2:11][OH:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC>CS(C)=O.C(Cl)Cl.CCOCC>[C:1]1([CH2:7][CH2:8][O:9][CH2:10][CH:11]=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
5
실험 절차
To 2-(2-phenylethoxy)-1-ethanol (0.25 g; 1.5 mmol) [J. Med. Chem., 1570 (1983)] dissolved in DMSO/CH2Cl2 (4 ml/2 ml) is added Et3N (1 ml; 7 mmol) followed by sulfur trioxide pyridine complex (1.2 g; 7.5 mmol). After 10 minutes, the reaction mixture is then diluted with Et2O and washed with brine, 1N HCl, NaHCO3 and brine, dried (MgSO4) and concentrated in vacuo to dryness. The residue is purified by column chromatography using CH2Cl2 to obtain 2-phenylethoxyacetaldehyde which is used directly in Step B.
후처리
- washwashed with brine, 1N HCl, NaHCO3 and brine
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo to dryness
- customThe residue is purified by column chromatography
출처 및 근거
- ORD 기록
- ord-275b6da7e74f405585cb46aea7d935ec
- 출처 데이터셋
- uspto-grants-1996_10
- 특허 번호
- US05561143
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