4-Methylbenzenethiol → HCID 10851611, 화합물

HRID 863905노트

반응식

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[F:9][C:10]([F:21])([F:20])[O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:16][C:15]2[CH:18]=[CH:19][C:12]([O:11][C:10]([F:9])([F:20])[F:21])=[CH:13][CH:14]=2)=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 78114-Methylbenzenethiol

HCID 27772614-(Trifluoromethoxy)benzyl Chloride

생성물 1

HCID 10851611HCID 10851611, 화합물수율 80.1%

실험 절차

The procedure of Example 87 is repeated using 11.8 g of p-thiocresol and 9.6 g of 4-(trifluoromethoxy)benzyl chloride. This affords 10.9 g of the desired product as white crystals. mp 74°-76° C. MS(CI): m/z 299(MH+). Calcd for C15H13F3OS: C=60.39, H=4.39, F=19.11, S=10.75 Found C=60.33, H=4.26, F=19.34, S=11.01

출처 및 근거

ORD 기록: ord-98e1b32b22294ace80b4a3c5e59c50d2
출처 데이터셋: uspto-grants-1996_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05561141

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