2,3-dihydro-6-methoxy-1H-isoindol-5-ol → alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile

참여 물질

역할	이름	HCID	투입량
반응물	2,3-dihydro-6-methoxy-1H-isoindol-5-ol	HCID 10241135	—
반응물	alpha-(5-Bromopentyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)thio]benzeneacetonitrile	HCID 10527448	—
생성물	alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile	HCID 10530307	74.2%

반응 단계

The procedure of Example 49 is used with 0.209 g of 2,3-dihydro-6-methoxy-1H-isoindol-5-ol (Example 105) and 0.57 g of α-(5-bromopentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile. This affords 0.5 g of the desired product as a gray foam. MS(Hi res): m/z Calcd for C31H36N2SO4 533.2474 Found 533.2460

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05561141
출처 데이터셋	uspto-grants-1996_10
ORD ID	ord-83166a7d0e524228b00628184e0c8227
출처 메모	uspto-grants-1996_10