3-Thieno[2,3-d]isoxazol-3-yl-phenol → (3-Fluoro-benzyl)-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine

HRID 8640

반응식

HRID 8640 반응식
C(OC([N:8]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=1)[CH2:9][CH2:10][O:11]S(C1C=CC(C)=CC=1)(=O)=O)=O)(C)(C)C.[O:30]1[C:34]2[CH:35]=[CH:36][S:37][C:33]=2[C:32]([C:38]2[CH:39]=[C:40](O)[CH:41]=[CH:42][CH:43]=2)=[N:31]1>>[F:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][CH:26]=1)[CH2:22][NH:8][CH2:9][CH2:10][O:11][C:42]1[CH:41]=[CH:40][CH:39]=[C:38]([C:32]2[C:33]3[S:37][CH:36]=[CH:35][C:34]=3[O:30][N:31]=2)[CH:43]=1

참가 물질

3

반응물 2

HCID 140972423-Thieno[2,3-d]isoxazol-3-yl-phenolHCID 23548235Toluene-4-sulfonic acid 2-[tert-butoxycarbonyl-(3-fluoro-benzyl)-amino]-ethyl ester

생성물 1

HCID 9907296(3-Fluoro-benzyl)-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine

실험 절차

The title compound is prepared from a mixture of toluene-4-sulfonic acid 2-[tert-butoxycarbonyl-(3-fluoro-benzyl)-amino]-ethyl ester and 3-thieno[2,3-d]isoxazol-3-yl-phenol essentially as described in Example 3, Scheme I, Step F. It is understood by one skilled in the art that the nitrogen may be deprotected by acid hydrolysis, to give the final, desired compound.

후처리

  1. custommay be deprotected by acid hydrolysis

출처 및 근거

ORD 기록
ord-1dd22aeb2ee24793a8ccc69ebe25774c
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091199B1

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