HCID 178443577, 화합물 → HCID 178442708, 화합물

반응식

Br[C:2]1[C:7]([F:8])=[N:6][C:5]([C:9]2[CH:14]=[CH:13][C:12]([C@H:15]3[CH2:20][CH2:19][C@H:18]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)=[CH:4][N:3]=1.[CH2:26]([Mg]Br)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]>>[F:8][C:7]1[C:2]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[N:3][CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C@H:15]3[CH2:20][CH2:19][C@H:18]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[N:6]=1

참가 물질

반응물 2

HCID 178443577HCID 178443577, 화합물

HCID 178444294HCID 178444294, 화합물

생성물 1

HCID 178442708HCID 178442708, 화합물수율 51.3%

실험 절차

In an analogous reaction to Example 1d, 2.75 g (6.80 mmol) of 2-bromo-3-fluoro-5-[4-(trans-4-pentylcyclohexyl)phenyl]pyrazine and 10.2 mmol of octylmagnesium bromide give 1.53 g of 2-fluoro-3-octyl-6-[4-(trans-4-pentylcyclohexyl)phenyl]pyrazine. ##STR21## The compound has the following phase sequence:

출처 및 근거

ORD 기록: ord-2c45862eb187419694f22d5a9f2e5b50
출처 데이터셋: uspto-grants-1996_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05562859

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