Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 2',3'-Didehydro-2',3'-dideoxycytidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Deoxycytidine | HCID 13711 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2',3'-Didehydro-2',3'-dideoxycytidine | HCID 64683 | — |
반응 단계
Namely, 2',3'-dideoxycytidine can be obtained according to the method of Horwitz et al in a way that N-benzoyl-2'-deoxy-3',5'-di-0-mesylcytidine derivable from 2'-deoxycytidine is refluxed with aqueous solution of sodium hydroxide in ethanol, then this is treated with dilute acetic acid, and further allowed to react with potassium tert-butoxide in dimethyl sulfoxide to obtain 2',3'-dideoxy-2',3'-didehydrocytidine, which is hydrogenated (J. Org. Chem., 32, 817, 1967).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05563049 |
| 출처 데이터셋 | uspto-grants-1996_10 |
| ORD ID | ord-26168c6f4eb240088b28307454eac529 |
| 출처 메모 | uspto-grants-1996_10 |