Boron tribromide → 4-(Chloromethyl)-2,6-dimethylphenol

HRID 864379노트

반응식

HRID 864379 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH3:12])[C:9]=1[O:10]C)[CH2:5][Cl:6].B(Br)(Br)Br.C(=O)(O)[O-].[Na+]>ClCCl>[CH3:12][C:8]1[CH:7]=[C:4]([CH:3]=[C:2]([CH3:1])[C:9]=1[OH:10])[CH2:5][Cl:6]

참가 물질

5

반응물 3

HCID 25134Boron tribromideHCID 516892Sodium BicarbonateHCID 194187985-(Chloromethyl)-2-methoxy-1,3-dimethylbenzene

생성물 1

HCID 2786614-(Chloromethyl)-2,6-dimethylphenol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3,5-Dimethyl-4-methoxybenzyl chloride (I, PREPARATION 4, 1.8 g) is added to a solution of boron tribromide (1.5 m) in dichloromethane (70 ml) at 78°. The solution is allowed gradually to warm to 20°-25° overnight. The reaction is poured into an aqueous sodium bicarbonate solution, and the phases are separated. The dichloromethane phase is washed once with water and then with concentrated hydrochloric acid. The dried (sodium sulfate) organic phase is concentrated under reduced pressure to give the title compound.

후처리

  1. temperatureto warm to 20°-25° overnight
  2. customthe phases are separated
  3. washThe dichloromethane phase is washed once with water
  4. dry with materialThe dried (sodium sulfate) organic phase
  5. concentrationis concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-67a4c4561dc345898bc20bd3eb8b8398
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05563142

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