Isopropylamine → 3-Chloro-N-(propan-2-yl)pyrazin-2-amine
반응식
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH:9]([NH2:12])([CH3:11])[CH3:10]>C1(C)C=CC=CC=1>[Cl:8][C:7]1[C:2]([NH:12][CH:9]([CH3:11])[CH3:10])=[N:3][CH:4]=[CH:5][N:6]=1참가 물질
4
실험 절차
A solution of 2,3-dichloropyrazine (2.0 g) and isopropylamine (2.3 g) in toluene (8 ml) is refluxed for 40 hr. The mixture is cooled and filtered to remove isopropylamine hydrochloride. The filtrate is concentrated in vacuo to a residue which is diluted with an aqueous sodium hydroxide solution (10%) and dichloromethane. The phases are separated. The dichloromethane phase is washed with saline, dried over sodium sulfate, and concentrated to give the title compound, NMR (CDCl3) 1.28, 4.21, 5.02, 7.54 and 7.94δ.
후처리
- temperatureThe mixture is cooled
- filtrationfiltered
- customto remove isopropylamine hydrochloride
- concentrationThe filtrate is concentrated in vacuo to a residue which
- additionis diluted with an aqueous sodium hydroxide solution (10%) and dichloromethane
- customThe phases are separated
- washThe dichloromethane phase is washed with saline
- dry with materialdried over sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-c73715c96fa54c8bbad23483852fe2d3
- 출처 데이터셋
- uspto-grants-1996_10
- 특허 번호
- US05563142
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