Potassium Hydroxide → 5-bromo-6-methoxy-1H-indole-2-carboxylic acid

HRID 864415노트

반응식

HRID 864415 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([O:15]C)=[O:14])=[CH:5]2.[OH-].[K+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([OH:15])=[O:14])=[CH:5]2

참가 물질

3

반응물 2

HCID 14797Potassium HydroxideHCID 16726758methyl 5-bromo-6-methoxy-1H-indole-2-carboxylate

생성물 1

HCID 194188695-bromo-6-methoxy-1H-indole-2-carboxylic acid

실험 절차

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 5-bromo-6-methoxyindole carboxylate (PREPARATION 81, 3.31 g) and potassium hydroxide (0.98 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.79, 7.03, 7.01 and 3.89 δ.

후처리

  1. customthe general procedure of PREPARATION 63

출처 및 근거

ORD 기록
ord-62808255a3494311863925c11acc816f
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05563142

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