Triethylamine → HCID 19418948, 화합물

HRID 864476노트

반응식

HRID 864476 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH2:8][N:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]1=[O:18].C(N(CC)CC)C>ClCCl>[S:2]([O:6][CH2:7][CH2:8][N:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]1=[O:18])([CH3:1])(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 2721073-(2-Hydroxyethyl)-1,3-benzothiazol-2(3H)-one

생성물 1

HCID 19418948HCID 19418948, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Methanesulfonyl chloride (1.625 ml, 2.4 g, 21 mmol) in dichloromethane (10 ml) was added dropwise with stirring to 3-(2-hydroxyethyl)benzothiazolin-2-one (3.9 g, 20 mmol) (J. J. D'Amico and F. G. Bollinger; J. Heterocyclic Chemistry 1988, 25, 1601).and triethylamine (3.478 ml, 2.525 g, 25 mmol) in dichloromethane (80 ml) and stirred for one hour at room temperature. The reaction mixture was then washed with water and dried (MgSO4), filtered and the solvent evaporated in-vacuo to give the title product.

후처리

  1. washThe reaction mixture was then washed with water
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customthe solvent evaporated in-vacuo

출처 및 근거

ORD 기록
ord-29298d48e9284d049fee26defbd9df5e
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05563147

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