Cyanamide → HCID 178512274, 화합물

HRID 864489

반응식

HRID 864489 반응식
[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]([NH:15][C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1)=S)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:22]#[C:23][NH2:24].C1(N=C=NC2CCCCC2)CCCCC1.C1(NC(NC2CCCCC2)=S)CCCCC1>C(#N)C.C(N(CC)CC)C>[C:23]([NH:24][C:13]([NH:12][CH2:11][CH2:10][CH2:9][CH2:8][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[N:15][C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1)#[N:22]

참가 물질

7

반응물 4

HCID 9864CyanamideHCID 10868DicyclohexylcarbodiimideHCID 727200DicyclohexylthioureaHCID 21467376N-(4-Phenoxybutyl)-N'-3-pyridylthiourea

생성물 1

HCID 178512274HCID 178512274, 화합물

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 8471Triethylamine용매

실험 절차

N-(4-Phenoxybutyl)-N'-3-pyridylthiourea (1.41 g) was dissolved in acetonitrile (10 ml), and cyanamide (400 mg), N,N'dicyclohexylcarbodiimide (1.95 g) and triethylamine (0.08 ml) were added. The mixture was stirred for 3 days at room temperature, when it was filtered, washed with acetonitrile, and ether to yield a solid mixture of the crude product and N,N'-dicyclohexylthiourea. The pure compound was obtained by extracting the mixture with 0.5N hydrochloric acid (16 ml), filtering and re-precipitation by addition of 9N sodium hydroxide to the filtrate.

후처리

  1. filtrationwhen it was filtered
  2. washwashed with acetonitrile, and ether
  3. customto yield
  4. customThe pure compound was obtained
  5. extractionby extracting the mixture with 0.5N hydrochloric acid (16 ml)
  6. filtrationfiltering
  7. customre-precipitation
  8. additionby addition of 9N sodium hydroxide to the filtrate

출처 및 근거

ORD 기록
ord-002fafce572d40b990540ea766675467
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05563160

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