Phosgene → 5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one

HRID 864638노트

반응식

HRID 864638 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][CH2:9][CH2:8][CH2:7]2.[C:12](Cl)(Cl)=[O:13]>C(O)(=O)C.ClC1C=CC=CC=1>[NH:1]1[C:2]2=[C:11]3[C:6](=[CH:5][CH:4]=[CH:3]2)[CH2:7][CH2:8][CH2:9][N:10]3[C:12]1=[O:13]

참가 물질

5

반응물 2

HCID 6371PhosgeneHCID 1046728-Quinolinamine, 1,2,3,4-tetrahydro-

생성물 1

HCID 156467025,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one수율 88%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 7964Chlorobenzene용매

실험 절차

To a solution of 10.77 g of 8-amino- 1,2,3,4-tetrahydroquinoline in glacial acetic acid (30 ml) was added dropwise a 21.75% solution of phosgene in chlorobenzene (30 ml), under nitrogen, with stirring. After the addition was complete, the mixture was heated under reflux, with stirring for one hr and evaporated. The residue was taken up in 10% ammonium hydroxide solution (75 ml) and extracted with dichloromethane. The organic extracts were dried over anhydrous magnesium sulfate, filtered, and the filtrate was evaporated. Ether was added to the residue and the mixture was chilled. The precipitate was collected to give 11.2 g (88%) of product.

후처리

  1. additionAfter the addition
  2. temperaturethe mixture was heated
  3. temperatureunder reflux
  4. stirringwith stirring for one hr
  5. customevaporated
  6. extractionextracted with dichloromethane
  7. dry with materialThe organic extracts were dried over anhydrous magnesium sulfate
  8. filtrationfiltered
  9. customthe filtrate was evaporated
  10. additionEther was added to the residue
  11. temperaturethe mixture was chilled
  12. customThe precipitate was collected

출처 및 근거

ORD 기록
ord-a807f0fc943244bf94d8db53170a255b
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05563272

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