Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate → ethyl 2-(4-amino-1H-imidazol-1-yl)octanoate

HRID 864673

반응식

HRID 864673 반응식
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[N:6]1[CH:10]=[C:9]([N+:11]([O-])=O)[N:8]=[CH:7]1)[CH3:2].[H][H]>[Pd]>[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[N:6]1[CH:10]=[C:9]([NH2:11])[N:8]=[CH:7]1)[CH3:2]

참가 물질

4

반응물 2

HCID 10062368Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 15222343ethyl 2-(4-amino-1H-imidazol-1-yl)octanoate수율 100.5%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A mixture of 5.9 g of 4-nitro-α-hexyl-1H-imidazole-1-acetic acid ethyl ester, 3 g of palladium-on-carbon and 150 ml of absolute alcohol were subjected to catalytic hydrogenation. Both theoretical and actual hydrogen uptake was 73 pounds. The catalyst was removed by filtration and the filtrate concentrated in vacuo to provide 5.3 g of the desired title intermediate which was used directly.

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-67ed31b84955402790252a01d00d41c0
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05563278

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