Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isonicotinic Acid → 2-Saccharinylmethyl pyridine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isonicotinic Acid | HCID 5922 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | N-Bromomethylsaccharin | HCID 15225519 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 2-Saccharinylmethyl pyridine-4-carboxylate | HCID 9861795 | 37% |
반응 단계
A mixture of isonicotinic acid (0.98 g, 0.008 mol), 2-bromomethylsaccharin (2.11 g, 0.008 mol), triethylamine (0.81 g, 0.008 mol) and xylene (25 ml) were refluxed for 1 hour. The solvent was removed in vacuo and the residue was partitioned between water and methylene chloride. The organic layer was separated and the solvent removed in vacuo. The solid residue was recrystallized from CH3CN to afford 0.9 g (37%) of 2-saccharinylmethyl pyridine-4-carboxylate as a yellow solid, m.p. 145°-146° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05563163 |
| 출처 데이터셋 | uspto-grants-1996_10 |
| ORD ID | ord-6457aa1183e04a4099e7ab2d812163ed |
| 출처 메모 | uspto-grants-1996_10 |