Trifluoroacetic acid → Trifluoroacetate

HRID 864785노트

반응식

HRID 864785 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:14]([NH:16][C@H:17]([C:25]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>ClCCl>[NH2:1][C@H:2]([C:14]([NH:16][C@H:17]([C:25]([O:27][CH2:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)=[O:26])[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1.[F:42][C:43]([F:48])([F:47])[C:44]([O-:46])=[O:45]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 10437796Boc-L-Asp(OBzl)-L-Phe-OBzl

생성물 2

HCID 84468TrifluoroacetateHCID 10004433L-Asp(OBzl)-L-Phe-OBzl

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Boc-L-Asp(OBzl)-L-Phe-OBzl (9.91 g) was dissolved in a mixture of trifluoroacetic acid (50 ml) and dichloromethane (50 ml). The resultant solution was stored at room temperature for 2 hr. The reaction mixture was evaporated to dryness to yield a residue which was triturated with ether, collected, washed thoroughly with ether and dried under high vacuum to yield L-Asp(OBzl)-L-Phe-OBzl, trifluoroacetate salt (8.36 g) as a white solid: NMR (CDCl3) δ2.88 (2H, m), 3.07 (2H, m), 4.33 (1H, m), 4.78 (1H, m), 5.02 (2H, s), 5.06 (2H, q), 6.20 (3H, v. br), 7.04 (2H, m), 7.26 (13H, m), 7.65 (1H, d); m/Z 461 (M +H)+.

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. customto yield a residue which
  3. customwas triturated with ether
  4. customcollected
  5. washwashed thoroughly with ether
  6. customdried under high vacuum

출처 및 근거

ORD 기록
ord-bf38199413a649d99841cecc956ed43d
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05563141

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