1,3-Diphthalimido-2-propanol → HCID 23374871, 화합물

HRID 864890노트

반응식

HRID 864890 반응식
[C:1]1(=[O:26])[N:5]([CH2:6][CH:7](O)[CH2:8][N:9]2[C:13](=[O:14])[C:12]3=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]3[C:10]2=[O:19])[C:4](=[O:21])[C:3]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:2]12.CC(C)=[O:29].OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[C:1]1(=[O:26])[N:5]([CH2:6][CH2:7][C:8]([N:9]2[C:13](=[O:14])[C:12]3=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]3[C:10]2=[O:19])=[O:29])[C:4](=[O:21])[C:3]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:2]12

참가 물질

4

반응물 2

HCID 971301,3-Diphthalimido-2-propanolHCID 131709961Jones' reagent

생성물 1

HCID 23374871HCID 23374871, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1,3-diphthalimido-2-hydroxypropane (1.00 g., 2,86 mmol) in 80 mL of acetone was added Jones reagent (chromium trioxide and sulfuric acid) until an orange color persisted. The excess oxidant was removed by the addition of 2-isopropanol until a green color was obtained and the solvents were evaporated under reduced pressure. The residue was partitioned between methylene chloride and water and the layers were separated. The organic layer was washed with water, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give 1,3-diphthalimido-3-oxopropane.

후처리

  1. customThe excess oxidant was removed by the addition of 2-isopropanol until a green color
  2. customwas obtained
  3. customthe solvents were evaporated under reduced pressure
  4. customThe residue was partitioned between methylene chloride and water
  5. customthe layers were separated
  6. washThe organic layer was washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-59981879cec74d92b1b8b10cc3648c47
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565184

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