Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 1-Benzyl-3-(chloromethyl)pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | (1-Benzylpyrrolidin-3-yl)methanol | HCID 5176654 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-Benzyl-3-(chloromethyl)pyrrolidine | HCID 12364518 | — |
반응 단계
To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723444 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-1537debbdfcd4c9fb2d97af472b6fc7c |
| 출처 메모 | uspto-grants-1998_03 |