참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-4'-methylacetophenone | HCID 69272 | — |
| 반응물 | N-(4-acetyl-3-hydroxyphenyl)acetamide | HCID 2775185 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[3-methyl-2-(4-methylbenzoyl)-1-benzofuran-6-yl]acetamide | HCID 19959494 | — |
반응 단계
0.72 g (3.75 mmol) of N-(4-acetyl-3-hydroxy-phenyl)acetamide and 0.81 g (4.1 mmol) of 2-bromo-4-methylacetophenone were dissolved in 5 ml DMF and 1,55 g (11.25 mmol) of potassium carbonate were added. The suspension was heated to 60° C. for 1 h and ethylacetate was added. The organic phase was washed three times with water, one time with a NaCl solution, dried over Na2SO4 and concentrated in vacuo. The residue was further purified by crystallisation (ethanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05565488 |
|---|
| 출처 데이터셋 | uspto-grants-1996_10 |
|---|
| ORD ID | ord-d0515c7e03ac4eb4b21163d172c08022 |
|---|
| 출처 메모 | uspto-grants-1996_10 |
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