Morpholine → 4-(Morpholin-4-yl)benzene-1-sulfonamide

HRID 865315노트

반응식

HRID 865315 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>C(Cl)Cl>[N:12]1([C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 1202314-Fluorobenzenesulfonamide

생성물 1

HCID 7354354-(Morpholin-4-yl)benzene-1-sulfonamide수율 73.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Fluorobenzenesulfonamide (5.50 g, 31.4 mmoles) was dissolved in 100 ml of morpholine (99.6 g, 1.14 moles) and was refluxed for 3 days. The solvent was removed by evaporation, yielding an orange oil. Methylene chloride (100 ml) was added, causing the oil to solidify. The solid was collected by filtration, then heated in 100 ml of ethanol. After cooling, the solid was collected by filtration, yielding 5.59 g (73%) of 4-(4-morpholinyl)benzenesulfonamide as a white solid.

후처리

  1. temperaturewas refluxed for 3 days
  2. customThe solvent was removed by evaporation
  3. customyielding an orange oil
  4. filtrationThe solid was collected by filtration
  5. temperatureheated in 100 ml of ethanol
  6. temperatureAfter cooling
  7. filtrationthe solid was collected by filtration

출처 및 근거

ORD 기록
ord-be990128fcec4b8eb871bc1c515b7d07
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565494

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