(3-Fluorophenyl)carbamic acid benzyl ester → (R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

HRID 865368

반응식

HRID 865368 반응식
[C:1]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=1)(OCC1C=CC=CC=1)=O.[C:19]([O:24][CH2:25][C@@H:26]1[O:28]C1)(=[O:23])CCC>O1CCCC1>[F:18][C:14]1[CH:13]=[C:12]([N:11]2[CH2:1][C@H:25]([CH2:26][OH:28])[O:24][C:19]2=[O:23])[CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 895321(3-Fluorophenyl)carbamic acid benzyl esterHCID 2724536(2R)-Oxiran-2-ylmethyl butanoate

생성물 1

HCID 11229590(R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of N-(carbobenzyloxy)-3-fluoroaniline (1.000 g, 4.08 mmol) in dry tetrahydrofuran (10 ml) is cooled with a dry ice/acetone bath to about -78° and then nbutyllithium (1.87 ml of a 1.6M mixture in hexanes, 2.91 mmol) is added. (R)-glycidyl butyrate (0.420 g or 0.413 ml, 2.91 mmol) is then added via syringe and the cooling bath allowed to dissipate overnight, with the reaction mixture reaching 20°-25°. The reaction mixture is quenched by the careful addition of saturated aqueous ammonium chloride, the entire mixture transferred to a separatory funnel with dichloromethane washings, and the mixture extracted with dichloromethane. The combined organic extracts are dried over sodium sulfate, filtered and concentrated under reduced pressure to give a concentrate which is purified by chromatography over silica gel, eluting with acetonitrile/chloroform (10/90) containing 1% methanol, to give the title compound.

후처리

  1. temperatureis cooled with a dry ice/acetone bath to about -78°
  2. customreaching 20°-25°
  3. customThe reaction mixture is quenched by the careful addition of saturated aqueous ammonium chloride
  4. customthe entire mixture transferred to a separatory funnel with dichloromethane washings
  5. extractionthe mixture extracted with dichloromethane
  6. dry with materialThe combined organic extracts are dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customto give
  10. concentrationa concentrate which
  11. customis purified by chromatography over silica gel
  12. washeluting with acetonitrile/chloroform (10/90)
  13. additioncontaining 1% methanol

출처 및 근거

ORD 기록
ord-b6a38fab3b1a4dcfa3842487012f291e
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565571

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