Thionyl Chloride → 2-Chloro-6-(trifluoromethoxy)-1,3-benzothiazole

반응식

N([C:3]1[S:4][C:5]2[CH:11]=[C:10]([O:12][C:13]([F:16])([F:15])[F:14])[CH:9]=[CH:8][C:6]=2[N:7]=1)N.S(Cl)([Cl:19])=O>>[Cl:19][C:3]1[S:4][C:5]2[CH:11]=[C:10]([O:12][C:13]([F:16])([F:15])[F:14])[CH:9]=[CH:8][C:6]=2[N:7]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 104221582-Hydrazinyl-6-(trifluoromethoxy)-1,3-benzothiazole

생성물 1

HCID 100379242-Chloro-6-(trifluoromethoxy)-1,3-benzothiazole

반응 조건

온도: 50 °C

실험 절차

49.4 g of 2-hydrazino-6-trifluoromethoxybenzothiazole are added over one hour to 97.9 g of thionyl chloride heated to 50° C. The mixture is then heated for one hour at this same temperature and then cooled to 0° C. After addition of 200 g of an ice/water mixture (1/1 by weight), the precipitate is filtered off and washed with twice 50 cm3 of water. 54.5 g of 2-chloro-6-trifluoromethoxybenzothiazole are thus obtained, melting at 50° C.

후처리

temperatureThe mixture is then heated for one hour at this same temperature
temperaturecooled to 0° C
filtrationthe precipitate is filtered off
washwashed with twice 50 cm3 of water

출처 및 근거

ORD 기록: ord-e6e2b4ad6f8e4edbb743a4d33e7773fe
출처 데이터셋: uspto-grants-1996_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05567822

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