4-Hydroxybenzyl Alcohol → 4-(3-tert-Butyl-4-methoxybenzoyloxymethyl)phenol

HRID 865895

반응식

HRID 865895 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:16]([C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:23](Cl)=[O:24])([CH3:19])([CH3:18])[CH3:17].O>C1COCC1>[C:16]([C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:23]([O:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1)=[O:24])([CH3:19])([CH3:17])[CH3:18]

참가 물질

6

반응물 4

HCID 1254-Hydroxybenzyl AlcoholHCID 962WaterHCID 1049PyridineHCID 136335553-Tert-butyl-4-methoxybenzoyl chloride

생성물 1

HCID 214745304-(3-tert-Butyl-4-methoxybenzoyloxymethyl)phenol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

1.24 g (0.01 mol) of 4-hydroxybenzenemethanol, 1 ml (0.01 mol) of pyridine and 50 ml of THF are introduced into a round-bottomed flask. While cooling in an icebath, a solution of 2.2 g (0.01 mol) of 3-tert-butyl-4-methoxybenzoyl chloride in 50 ml of THF is introduced dropwise and the mixture is stirred at room temperature for 24 h. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated. The residue obtained is purified by chromatography on a silica column and eluted with a mixture of dichloromethane and ethyl ether (97:3).

후처리

  1. temperatureWhile cooling in an icebath
  2. extractionthe mixture is extracted with ethyl ether
  3. customthe organic phase is separated after settling
  4. dry with materialdried over magnesium sulphate
  5. customevaporated
  6. customThe residue obtained
  7. customis purified by chromatography on a silica column
  8. washeluted with a mixture of dichloromethane and ethyl ether (97:3)

출처 및 근거

ORD 기록
ord-d3203e04ad834356b6ffc7d05cf4d3f9
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05567721

연결된 노트

불러오는 중…