Nitric Acid → 2-(3-Methyl-4-nitrophenyl)benzonitrile

HRID 866264

반응식

HRID 866264 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][CH:7]=1.[N+:16]([O-])([OH:18])=[O:17].S(=O)(=O)(O)O>O>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][C:7]=1[N+:16]([O-:18])=[O:17]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 13942432-(3-Methylphenyl)benzonitrile

생성물 1

HCID 214689052-(3-Methyl-4-nitrophenyl)benzonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-(3-Methylphenyl)benzonitrile (18.1 mmoles, 3.5 g) was added slowly at -5° C. to a mixture of 10 ml nitric acid and 10 ml sulfuric acid. After 5 minutes, the reaction was diluted with cold water. The solid was collected, dissolved in THF. The solution was dried and concentrated. The solid was recrystallized from ether and hexane to yield 2.45 g of 2-(3-methyl-4-nitrophenyl)benzonitrile. (MS)

후처리

  1. customThe solid was collected
  2. dissolutiondissolved in THF
  3. customThe solution was dried
  4. concentrationconcentrated
  5. customThe solid was recrystallized from ether and hexane

출처 및 근거

ORD 기록
ord-3c1b5786e2664901890ebc993329f284
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05569768

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