Ethyl Acetate → HCID 178509648, 화합물

HRID 866278노트

반응식

HRID 866278 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=2[C:11]#[N:12])[CH:5]=[CH:6][C:7]=1[NH2:8].C(O[CH2:21][CH3:22])(=O)C>C(O)C.[Cl-].[Na+].O>[CH2:21]([C:22]1[NH:8][C:7]2[CH:6]=[CH:5][C:4]([C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[C:11]#[N:12])=[CH:3][C:2]=2[N:1]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 21468845HCID 21468845, 화합물

생성물 1

HCID 178509648HCID 178509648, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 57417360Sodium chloride; water용매

실험 절차

2-(3,4-Diaminophenyl)benzonitrile (2.4 moles, 0.50 g) was dissolved in 3 ml ethanol. Ethyl phenylacetamidate hydrochloride (2.88 mmoles, 0.573 g) (prepared from HCl gas bubbled through benzyl cyanide and ethanol) was added. The reaction was warmed on a steam bath for 10 minutes. Ethyl acetate and brine were added. The organic phase was separated, dried and concentrated. The product was precipitated from ethyl acetate and hexane and filtered to yield 290 mg of 2-benzyl-5-(2-cyanophenyl)-1H-benzimidazole. (MS)

후처리

  1. temperatureThe reaction was warmed on a steam bath for 10 minutes
  2. customThe organic phase was separated
  3. customdried
  4. concentrationconcentrated
  5. customThe product was precipitated from ethyl acetate and hexane
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-fbf4518337d542f5a85df8952719ae32
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05569768

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