참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzenesulfonic Acid | HCID 7371 | — |
| 반응물 | N-[[(3,5-dichlorophenyl)amino]carbonyl]glycine | HCID 595293 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | 3-(3,5-Dichlorophenyl)-2,4-imidazolidinedione | HCID 168691 | 90.6% |
반응 단계
To a suspension of 3-(3,5-dichlorophenyl)-ureidoacetic acid (26.3 g.) in chlorobenzene (180 cc.) is added benzenesulphonic acid (1.2 g. representing 0.068 mol per mol of ureidoacetic acid). The water formed in the reaction is removed by azeotropic distillation. After 30 minutes' distillation, a limpid solution is obtained. After cooling to about 15° C, the precipitate formed is filtered off and washed on the filter with ethanol (25 cc.) at 10° C. After drying, 3-(3,5-dichlorophenyl)-hydantoin (22.2 g.) melting at 199° C is obtained. Yield: 90.5%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04099008 |
|---|
| 출처 데이터셋 | uspto-grants-1978_07 |
|---|
| ORD ID | ord-c2f494f9b56c4c209ba7eec1f8842a1e |
|---|
| 출처 메모 | uspto-grants-1978_07 |
|---|
