Prostaglandin D2 → Pgd1

HRID 866510

반응식

HRID 866510 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]([OH:25])/[CH:7]=[CH:8]/[C@H:9]1[C:13](=[O:14])[CH2:12][C@H:11]([OH:15])[C@@H:10]1[CH2:16]/[CH:17]=[CH:18]\[CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23].[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]([OH:25])/[CH:7]=[CH:8]/[C@H:9]1[C:13](=[O:14])[CH2:12][C@H:11]([OH:15])[C@@H:10]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23]

참가 물질

5

반응물 2

HCID 448457Prostaglandin D22회HCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 5280936Pgd1

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of PGD2 (Example 16) in ethyl acetate is shaken with hydrogen at about one atmospheric pressure at ambient temperature in the presence of a 5 percent palladium-on-charcoal catalyst. Hydrogenation is stopped when one equivalent of hydrogen per equivalent of PGD2 is absorbed. Catalyst is removed by filtration and the filtrate is then concentrated under reduced pressure and the residue chromatographed on silica gel, eluting with ethyl acetate and Skellysolve B. Fractions shown to contain pure product are combined yielding the title compound.

후처리

  1. customis absorbed
  2. customCatalyst is removed by filtration
  3. concentrationthe filtrate is then concentrated under reduced pressure
  4. customthe residue chromatographed on silica gel
  5. washeluting with ethyl acetate and Skellysolve B

출처 및 근거

ORD 기록
ord-647a29259fbb4f02a4a0d4a4185f6aa6
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04099014

연결된 노트

불러오는 중…