Water → HCID 22762753, 화합물

HRID 866852노트

반응식

HRID 866852 반응식
Cl[CH2:2][C:3]1[O:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.[C:15]1(=[O:25])[NH:19][C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12.[K].O>CN(C)C=O>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[O:4][C:3]([CH2:2][N:19]3[C:18](=[O:20])[C:17]4=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]4[C:15]3=[O:25])=[N:7][CH:6]=2)=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 7369662-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazoleHCID 24194345Phthalimide potassium salt

생성물 1

HCID 22762753HCID 22762753, 화합물수율 71%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A suspension of 2.3 g of 2-chloromethyl-5-(4-chlorophenyl) oxazole and 1.94 g of potassium phthalimide in 15 ml of dimethylformamide was stirred at room temperature for one hour. The reaction mixture was poured into 300 ml of water, and the resultant precipitate was filtered and recrystallized from ethanol to give 2.4 g (71 percent) of N-[5-(4-chlorophenyl)-2-oxazolyl]methylphthalimide.

후처리

  1. filtrationthe resultant precipitate was filtered
  2. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-2c11c45f037d45448040d4a98aeb33bb
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04101660

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