Ammonia → N-(4-Chlorobenzhydryl)thiourea

HRID 866857

반응식

HRID 866857 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH:6]([N:13]=[C:14]=[S:15])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH3:18]>CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]([NH:13][C:14]([NH2:18])=[S:15])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 218286174-Chlorobenzhydryl isothiocyanate

생성물 1

HCID 21312364N-(4-Chlorobenzhydryl)thiourea

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

A solution of 4-chlorobenzhydryl isothiocyanate [5.2g (0.02M)] in 50 mls of dry ether at 0° C is treated with NH3 (anhyd.) for 1/2 hour while maintaining a temperature of 0° C with stirring. Stirring is continued an additional 1.5 hours at 9° to 10° C. during which time a white solid appears. The crude thiourea is filtered and washed thoroughly with ether; mp 173°-5° C. The filtrate is concentrated in vacuo to yield additional product. The combined crops of N-(4-chlorobenzhydryl) thiourea are used in the next step without further purification.

후처리

  1. stirringStirring
  2. filtrationThe crude thiourea is filtered
  3. washwashed thoroughly with ether
  4. concentrationThe filtrate is concentrated in vacuo
  5. customto yield additional product
  6. customThe combined crops of N-(4-chlorobenzhydryl) thiourea are used in the next step without further purification

출처 및 근거

ORD 기록
ord-edd07cff828446d087e0a9b78a66eaf4
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04101659

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