Dimethylamine → 3-Dimethylamino-1,1-diphenyl-propan-2-ol

HRID 866946노트

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HRID 866946 반응식
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]([OH:11])[CH2:9]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][NH:19][CH3:20]>C(O)C>[CH3:18][N:19]([CH3:20])[CH2:9][CH:8]([OH:11])[CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 125490671,1-Diphenyl-3-bromopropan-2-ol

생성물 1

HCID 125491223-Dimethylamino-1,1-diphenyl-propan-2-ol수율 75%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1,1-Diphenyl-3-bromopropan-2-ol (500mg.) prepared as described in Example 20 was treated with excess dimethylamine in ethanol and the solution allowed to stand overnight. Solvent was removed by evaporation and the residue dissolved in dilute hydrochloric acid and ether. Basification of the acid extract and isolation through ether in the usual manner gave 3-dimethylamino-1,1-diphenyl-propan-2-ol (330mg, 75%) m.p. 72° - 73°

후처리

  1. customSolvent was removed by evaporation
  2. dissolutionthe residue dissolved in dilute hydrochloric acid
  3. extractionBasification of the acid extract

출처 및 근거

ORD 기록
ord-53b55bb22b004e56be03f533f7f4fbff
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04101676

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