Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Indole → 1-(4-benzoyl-1-piperidyl)-2-(1H-indol-3-yl)ethane-1,2-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Indole | HCID 798 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 3-Indoleglyoxylyl chloride | HCID 89952 | — |
| 반응물 | Phenyl(piperidin-4-yl)methanone | HCID 226102 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-(4-benzoyl-1-piperidyl)-2-(1H-indol-3-yl)ethane-1,2-dione | HCID 20311711 | — |
반응 단계
A sample of an indole of the formula ##STR7## in a solvent such as anhydrous ether is allowed to react with oxalyl chloride at a temperature of from -15° to 15° C. for from a couple of minutes to one hour to produce a mixture of a corresponding 3-indoleglyoxyloyl chloride in the solvent which is then added to a cooled solution of 4-benzoylpiperidine in a suitable organic solvent such as chloroform optionally containing an acid scavenger such as potassium carbonate and allowing the mixture to react at a temperature of from 15° to 40° C. for a few minutes to 12 hours to produce a 4-benzoyl-1-(indol-3-ylglyoxyloyl)piperidine of the formula ##STR8##
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04101663 |
| 출처 데이터셋 | uspto-grants-1978_07 |
| ORD ID | ord-dc7ca59438ab48e38566a4526c4c79c1 |
| 출처 메모 | uspto-grants-1978_07 |