Ethanol → HCID 53702167, 화합물

HRID 867351노트

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HRID 867351 반응식
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[C:5]=1[CH3:21])(=[O:3])[CH3:2].[F:22][C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH:25]=O.C(O)C.[OH-].[K+]>C(OCC)(=O)C>[F:22][C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH:25]=[CH:2][C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[C:5]=1[CH3:21])=[O:3]

참가 물질

6

반응물 4

HCID 702EthanolHCID 14797Potassium HydroxideHCID 67970o-FluorobenzaldehydeHCID 13645595JWH-001

생성물 1

HCID 53702167HCID 53702167, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Following a procedure similar to that described in Example 20A above, 14.75 g. (0.0516 mole) of 3-acetyl-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole (Example 20A) was reacted with 2-fluorobenzaldehyde in 260 ml. of ethanol in the presence of 3.44 g. (0.061 mole) of potassium hydroxide pellets and the product, in the form of the free base, recrystallized from ethyl acetate to give 10.0 (54%) of 3-(2-fluorocinnamoyl)-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole. m.p. 113°-116° C.

출처 및 근거

ORD 기록
ord-df6268c2b61a424ea6a2d45af596f05b
출처 데이터셋
uspto-grants-1988_10
특허 번호
USRE032761

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