Thionyl Chloride → 2-(Pentyloxy)propanoyl chloride

HRID 867357노트

반응식

HRID 867357 반응식
[CH2:1]([O:6][CH:7]([CH3:11])[C:8](O)=[O:9])[CH2:2][CH2:3][CH2:4][CH3:5].S(Cl)([Cl:14])=O>>[CH2:1]([O:6][CH:7]([CH3:11])[C:8]([Cl:14])=[O:9])[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 14693035HCID 14693035, 화합물

생성물 1

HCID 146930362-(Pentyloxy)propanoyl chloride

실험 절차

10 ml of thionyl chloride was added to 2.0 g of α-pentyloxypropionic acid and the mixture was refluxed under heat for 2 hours. Excess of thionyl chloride was distilled off to obtain α-pentyloxypropionic acid chloride. 20 ml of dry pyridine was added thereto, and 7.0 g of 5-decyl-2-(4-hydroxyphenyl)pyrimidine dissolved in 50 ml of dry benzene was further added dropwise. After the addition, the mixture was refluxed under heat, charged into ice water and extracted with benzene. The extractwas purified with a silica gel column chromatography to obtain 5-decyl-2-(4'-α-pentyloxypropanoyloxyphenyl)pyrimidine.

후처리

  1. temperaturethe mixture was refluxed
  2. temperatureunder heat for 2 hours
  3. distillationExcess of thionyl chloride was distilled off

출처 및 근거

ORD 기록
ord-dfa858b29963415888de7889351e7c5a
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04775223

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